For the second time in three weeks, the St. Louis Rams and San Francisco 49ers battled past regulation in a hard-fought NFC West tussle.

But unlike their Week 10 meeting, Sunday's eerily similar tilt ended with a winner, as Greg Zuerlein connected on a 54-yard field goal with 26 seconds remaining in OT to give the Rams a 16-13 victory at Edward Jones Dome.

Both Zuerlein and David Akers missed field goals in overtime during a 17-17 outcome three weeks ago. Akers was off the mark again in the rematch, narrowly pushing a 51-yard try wide right with 4:11 remaining in the extra session.

The Rams gained one first down after the miss, and on 4th-and-inches from the San Francisco 37-yard line, Zuerlein answered the call to give the Rams their second straight win and the rookie's seventh make of 50-plus yards this year.

St. Louis (5-6-1) remained unbeaten against division foes despite being held to 293 yards. Steven Jackson, one week after amassing a season-high 139 rushing yards, was limited to 48 yards on 21 carries, while Sam Bradford completed 26-of-39 passes for 221 yards.

This was the first loss for division-leading San Francisco (8-3-1) since a 26-3 thumping by the New York Giants on Oct. 14.

Colin Kaepernick, in his third game as starter after Alex Smith suffered a concussion against the Rams, had two costly mistakes in the setback. The inexperienced signal-caller was whistled for a safety and lost a fumble that resulted in a tying touchdown and two-point conversion with 3:04 to play in the fourth quarter.